Genetic Features of MCR-1-Producing Colistin-Resistant Escherichia coli Isolates in South Africa.
Antimicrob Agents Chemother
; 60(7): 4394-7, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-27161623
ABSTRACT
A series of colistin-resistant Escherichia coli clinical isolates was recovered from hospitalized and community patients in South Africa. Seven clonally unrelated isolates harbored the mcr-1 gene located on different plasmid backbones. Two distinct plasmids were fully sequenced, and identical 2,600-bp-long DNA sequences defining a mcr-1 cassette were identified. Promoter sequences responsible for the expression of mcr-1, deduced from the precise identification of the +1 transcription start site for mcr-1, were characterized.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colistina
/
Escherichia coli
/
Antibacterianos
País/Região como assunto:
Africa
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article