Development and validation of an instrument to assess treatment adherence for each individual drug taken by a patient.
BMJ Open
; 6(5): e010510, 2016 05 10.
Article
em En
| MEDLINE
| ID: mdl-27165645
ABSTRACT
OBJECTIVE:
To develop and validate an instrument to assess adherence to each individual drug taken by patients undergoing long-term treatment.DESIGN:
Multicentre prospective observational validation study.SETTING:
Six general practitioners' clinics and 6 university hospitals in Paris, France.PARTICIPANTS:
Patients 18â years and older receiving at least one long-term treatment.METHODS:
The instrument was developed from a literature search and interviews with experts. Clarity and wording were assessed during pilot testing with 51 patients. The tool was validated in a sample of consecutive patients. We assessed agreement between adherence measured with our tool and drug diaries and compared measurements from our instrument with (1) the Lu instrument; (2) the Adherence Estimator (AE); (3) patient's adherence assessed by physicians; (4) the Morisky Medication Adherence Scale-4 items (MMAS-4); and (5) the Treatment Burden Questionnaire (TBQ). Reliability was assessed by a test-retest method.RESULTS:
A total of 243 patients taking 961 drugs were recruited in 2014. We found good agreement between adherence measured by our tool and drug diaries (intraclass correlation coefficient (ICC) 0.69, 95% CI 0.34 to 0.91) and a linear relationship between measurement with our tool and (1) the Lu instrument (p<0.01); (2) 2 items of the AE (perceived need for medication (p<0.01) and concerns about medication (p<0.01)); (3) patients' adherence assessed by their physicians (p<0.01); (4) the MMAS-4 (p<0.01) and (5) the TBQ (p<0.01). Reliability of the retest was good (ICC 0.67, 95% CI 0.42 to 0.85).CONCLUSIONS:
We developed an instrument with acceptable validity and reliability to assess adherence for each drug taken by patients, usable in hospital and primary care settings.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inquéritos e Questionários
/
Adesão à Medicação
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adult
/
Aged
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Female
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Humans
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Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article