Changing the selectivity profile - from substrate analog inhibitors of thrombin and factor Xa to potent matriptase inhibitors.

Maiwald, Alexander; Hammami, Maya; Wagner, Sebastian; Heine, Andreas; Klebe, Gerhard; Steinmetzer, Torsten

Maiwald, Alexander; Hammami, Maya; Wagner, Sebastian; Heine, Andreas; Klebe, Gerhard; Steinmetzer, Torsten.

Afiliação

Maiwald A; a Department of Pharmacy , Institute of Pharmaceutical Chemistry, Philipps University , Marburg , Germany.
Hammami M; a Department of Pharmacy , Institute of Pharmaceutical Chemistry, Philipps University , Marburg , Germany.
Wagner S; a Department of Pharmacy , Institute of Pharmaceutical Chemistry, Philipps University , Marburg , Germany.
Heine A; a Department of Pharmacy , Institute of Pharmaceutical Chemistry, Philipps University , Marburg , Germany.
Klebe G; a Department of Pharmacy , Institute of Pharmaceutical Chemistry, Philipps University , Marburg , Germany.
Steinmetzer T; a Department of Pharmacy , Institute of Pharmaceutical Chemistry, Philipps University , Marburg , Germany.

J Enzyme Inhib Med Chem ; 31(sup1): 89-97, 2016.

Article em En | MEDLINE | ID: mdl-27168215

Assuntos

Inibidores Enzimáticos/farmacologia; Fator Xa/metabolismo; Serina Endopeptidases/metabolismo; Trombina/antagonistas & inibidores; Relação Dose-Resposta a Droga; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/química; Inibidores do Fator Xa/farmacologia; Humanos; Modelos Moleculares; Estrutura Molecular; Relação Estrutura-Atividade; Trombina/metabolismo

Palavras-chave

Benzamidines; X-ray structure; matriptase; protease inhibition; trypsin

Buscar no Google

Imprimir

XML

PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Serina Endopeptidases / Trombina / Fator Xa / Inibidores Enzimáticos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Buscar no Google

Imprimir

XML

PubMed Links