Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness.
Clin Neurophysiol
; 127(6): 2414-22, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-27178861
ABSTRACT
OBJECTIVES:
Ketamine is an N-methyl-d-aspartate (NMDA) receptor antagonist commonly administered as a general anesthetic. However, neural circuit mechanisms to explain ketamine anesthesia-induced unconsciousness in humans are yet to be clearly defined. Disruption of frontal-parietal network connectivity has been proposed as a mechanism to explain this brain state. However, this mechanism was recently demonstrated at subanesthetic doses of ketamine in awake-patients. Therefore, we investigated whether there is an electroencephalogram (EEG) signature specific for ketamine anesthesia-induced unconsciousness.METHODS:
We retrospectively studied the EEG in 12 patients who received ketamine for the induction of general anesthesia. We analyzed the EEG dynamics using power spectral and coherence methods.RESULTS:
Following the administration of a bolus dose of ketamine to induce unconsciousness, we observed a "gamma burst" EEG pattern that consisted of alternating slow-delta (0.1-4Hz) and gamma (â¼27-40Hz) oscillations. This pattern was also associated with increased theta oscillations (â¼4-8Hz) and decreased alpha/beta oscillations (â¼10-24Hz).CONCLUSIONS:
Ketamine anesthesia-induced unconsciousness is associated with a gamma burst EEG pattern.SIGNIFICANCE:
The EEG signature of ketamine anesthesia-induced unconsciousness may offer new insights into NMDA circuit mechanisms for unconsciousness.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Anestésicos Gerais
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Ritmo Gama
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Ketamina
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article