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N-acyl dopamines induce cell death in PC12 cell line via induction of nitric oxide generation and oxidative stress.
Ashba, A M; Akimov, M G; Gretskaya, N M; Bezuglov, V V.
Afiliação
  • Ashba AM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
  • Akimov MG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia. akimovmike@yandex.ru.
  • Gretskaya NM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
  • Bezuglov VV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
Dokl Biochem Biophys ; 467(1): 81-4, 2016 Mar.
Article em En | MEDLINE | ID: mdl-27193703
ABSTRACT
It was shown that dopamine amides of arachidonic, oleic, and docosahexaenoic acids exhibit toxicity with respect to PC12 pheochromocytoma cell line. The mechanism of realization of the cytotoxic effect of acyl dopamines is the induction of oxidative stress. This event is preceded by triggering the synthesis of nitric oxide.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Morte Celular / Estresse Oxidativo / Ácidos Graxos Insaturados / Óxido Nítrico Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Morte Celular / Estresse Oxidativo / Ácidos Graxos Insaturados / Óxido Nítrico Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article