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Determination of Antibody-Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation.
Bessire, Andrew J; Ballard, T Eric; Charati, Manoj; Cohen, Justin; Green, Michael; Lam, My-Hanh; Loganzo, Frank; Nolting, Birte; Pierce, Betsy; Puthenveetil, Sujiet; Roberts, Lee; Schildknegt, Klaas; Subramanyam, Chakrapani.
Afiliação
  • Bessire AJ; Pharmacokinetics, Dynamics and Metabolism, ∥Worldwide Medicinal Chemistry, and ¶Pharmaceutical Sciences Chemical R&D, Pfizer Worldwide R&D , Groton, Connecticut 06340, United States.
  • Ballard TE; Oncology Research Unit, and ⊥Bioprocess R&D, Pfizer Worldwide R&D , Pearl River, New York 10965, United States.
  • Charati M; Worldwide Medicinal Chemistry, and §Global Biotherapeutics Technologies, Pfizer Worldwide R&D , Cambridge, Massachusetts 02139, United States.
  • Cohen J; Pharmacokinetics, Dynamics and Metabolism, ∥Worldwide Medicinal Chemistry, and ¶Pharmaceutical Sciences Chemical R&D, Pfizer Worldwide R&D , Groton, Connecticut 06340, United States.
  • Green M; Oncology Research Unit, and ⊥Bioprocess R&D, Pfizer Worldwide R&D , Pearl River, New York 10965, United States.
  • Lam MH; Worldwide Medicinal Chemistry, and §Global Biotherapeutics Technologies, Pfizer Worldwide R&D , Cambridge, Massachusetts 02139, United States.
  • Loganzo F; Pharmacokinetics, Dynamics and Metabolism, ∥Worldwide Medicinal Chemistry, and ¶Pharmaceutical Sciences Chemical R&D, Pfizer Worldwide R&D , Groton, Connecticut 06340, United States.
  • Nolting B; Oncology Research Unit, and ⊥Bioprocess R&D, Pfizer Worldwide R&D , Pearl River, New York 10965, United States.
  • Pierce B; Worldwide Medicinal Chemistry, and §Global Biotherapeutics Technologies, Pfizer Worldwide R&D , Cambridge, Massachusetts 02139, United States.
  • Puthenveetil S; Pharmacokinetics, Dynamics and Metabolism, ∥Worldwide Medicinal Chemistry, and ¶Pharmaceutical Sciences Chemical R&D, Pfizer Worldwide R&D , Groton, Connecticut 06340, United States.
  • Roberts L; Oncology Research Unit, and ⊥Bioprocess R&D, Pfizer Worldwide R&D , Pearl River, New York 10965, United States.
  • Schildknegt K; Worldwide Medicinal Chemistry, and §Global Biotherapeutics Technologies, Pfizer Worldwide R&D , Cambridge, Massachusetts 02139, United States.
  • Subramanyam C; Pharmacokinetics, Dynamics and Metabolism, ∥Worldwide Medicinal Chemistry, and ¶Pharmaceutical Sciences Chemical R&D, Pfizer Worldwide R&D , Groton, Connecticut 06340, United States.
Bioconjug Chem ; 27(7): 1645-54, 2016 Jul 20.
Article em En | MEDLINE | ID: mdl-27206324
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Imunoconjugados / Liberação Controlada de Fármacos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Imunoconjugados / Liberação Controlada de Fármacos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article