Spontaneous olfactory neuroepithelioma in a domestic medaka (Oryzias latipes).
Cancer Res
; 49(11): 2994-8, 1989 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-2720659
ABSTRACT
Tumors of the central nervous system in fish are rare, and only six cases of spontaneous olfactory neuroepithelioma have been reported. This is the seventh case, found in a medaka, Oryzias latipes. The tumor was noted near the right olfactory orifice and finally measured 1.5 mm in diameter. Histologically the tumor consisted of undifferentiated neuroblasts forming a few true rosettes. Mitosis was frequently observed. Tumor cells stained diffusely for neuron-specific enolase and sporadically for neurofilament proteins by immunohistochemical procedures. Additionally a few large tumor cells were positively stained for S-100 protein. Electron microscopy revealed that the tumor cells had extended cytoplasm in which parallel neurotubules and a few neuroendocrine granules were noted. In the perinuclear region, bundles of intermediate filaments and neuroendocrine granules were seen. Single cilia and a pair of centrioles were occasionally found, but no ciliated cells were found in this tumor. Some large tumor cells contained electron-dense intracytoplasmic inclusions which showed a crystalloid structure by high-magnification electron microscopy; however, this type of crystalloid has never been reported in neuronal tumors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tumores Neuroectodérmicos Primitivos Periféricos
/
Doenças dos Peixes
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article