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Pharmacokinetic indices for cefovecin after single-dose administration to adult sea otters (Enhydra lutris).
Lee, E A; Byrne, B A; Young, M A; Murray, M; Miller, M A; Tell, L A.
Afiliação
  • Lee EA; Departments of Medicine and Epidemiology, University of California, Davis, CA, USA.
  • Byrne BA; Department of Pathology, Microbiology and Immunology, University of California, Davis, CA, USA.
  • Young MA; Monterey Bay Aquarium, Monterey, CA, USA.
  • Murray M; Monterey Bay Aquarium, Monterey, CA, USA.
  • Miller MA; Department of Fish and Wildlife, Office of Spill Prevention and Response, Marine Wildlife Veterinary Care and Research Center California, Santa Cruz, CA, USA.
  • Tell LA; Departments of Medicine and Epidemiology, University of California, Davis, CA, USA. latell@ucdavis.edu.
J Vet Pharmacol Ther ; 39(6): 625-628, 2016 Dec.
Article em En | MEDLINE | ID: mdl-27212054
Seven sea otters received a single subcutaneous dose of cefovecin at 8 mg/kg body weight. Plasma samples were collected at predetermined time points and assayed for total cefovecin concentrations using ultra-performance liquid chromatography and tandem mass spectrometry. The mean (±SD) noncompartmental pharmacokinetic indices were as follows: CMax (obs) 70.6 ± 14.6 µg/mL, TMax (obs) 2.9 ± 1.5 h, elimination rate constant (kel ) 0.017 ± 0.002/h, elimination half-life (t1/2kel) 41.6 ± 4.7 h, area under the plasma concentration-vs.-time curve to last sample (AUClast) 3438.7 ± 437.7 h·µg/mL and AUC extrapolated to infinity (AUC0→∞ ) 3447.8 ± 439.0 h·µg/mL. The minimum inhibitory concentrations (MIC) for select isolates were determined and used to suggest possible dosing intervals of 10 days, 5 days, and 2.5 days for gram-positive, gram-negative, and Vibrio parahaemolyticus bacterial species, respectively. This study found a single subcutaneous dose of cefovecin sodium in sea otters to be clinically safe and a viable option for long-acting antimicrobial therapy.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lontras / Cefalosporinas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lontras / Cefalosporinas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article