Investigation of low recovery in the free drug assay for antibody drug conjugates by size exclusion-reversed phase two dimensional-liquid chromatography.

Li, Yi; Stella, Cinzia; Zheng, Laura; Bechtel, Charity; Gruenhagen, Jason; Jacobson, Fred; Medley, Colin D

Li, Yi; Stella, Cinzia; Zheng, Laura; Bechtel, Charity; Gruenhagen, Jason; Jacobson, Fred; Medley, Colin D.

Afiliação

Li Y; Small Molecule Pharmaceutical Sciences, Genentech, South San Francisco, CA 94080, United States.
Stella C; Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, United States.
Zheng L; Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, United States.
Bechtel C; Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, United States.
Gruenhagen J; Small Molecule Pharmaceutical Sciences, Genentech, South San Francisco, CA 94080, United States.
Jacobson F; Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, United States.
Medley CD; Small Molecule Pharmaceutical Sciences, Genentech, South San Francisco, CA 94080, United States. Electronic address: medley.colin@gene.com.

J Chromatogr B Analyt Technol Biomed Life Sci ; 1032: 112-118, 2016 Oct 01.

Article em En | MEDLINE | ID: mdl-27212187

Assuntos

Cromatografia em Gel/métodos; Cromatografia de Fase Reversa/métodos; Imunoconjugados/química; Interações Hidrofóbicas e Hidrofílicas; Maleimidas/química

Palavras-chave

2D-LC; Antibody drug conjugates; Hydrophobic interaction chromatography

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatografia em Gel / Imunoconjugados / Cromatografia de Fase Reversa Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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