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Multiplex PCR assay underreports true bloodstream infections with coagulase-negative staphylococci in hematological patients with febrile neutropenia.
Reers, Yvonne; Idelevich, Evgeny A; Pätkau, Hanna; Sauerland, Maria Cristina; Tafelski, Sascha; Nachtigall, Irit; Berdel, Wolfgang E; Peters, Georg; Silling, Gerda; Becker, Karsten.
Afiliação
  • Reers Y; Institute of Medical Microbiology, University Hospital Münster, Domagkstr. 10, 48149 Münster, Germany.
  • Idelevich EA; Institute of Medical Microbiology, University Hospital Münster, Domagkstr. 10, 48149 Münster, Germany.
  • Pätkau H; Institute of Medical Microbiology, University Hospital Münster, Domagkstr. 10, 48149 Münster, Germany.
  • Sauerland MC; Institute of Biostatistics and Clinical Research, University of Münster, Schmeddingstraße 56, 48149 Münster, Germany.
  • Tafelski S; Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany.
  • Nachtigall I; Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany.
  • Berdel WE; Department of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1/A1, 48149 Münster, Germany.
  • Peters G; Institute of Medical Microbiology, University Hospital Münster, Domagkstr. 10, 48149 Münster, Germany.
  • Silling G; Department of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1/A1, 48149 Münster, Germany.
  • Becker K; Institute of Medical Microbiology, University Hospital Münster, Domagkstr. 10, 48149 Münster, Germany. Electronic address: kbecker@uni-muenster.de.
Diagn Microbiol Infect Dis ; 85(4): 413-5, 2016 Aug.
Article em En | MEDLINE | ID: mdl-27220608
ABSTRACT
SeptiFast multiplex PCR assay was evaluated for detecting true bloodstream infections (BSIs) with coagulase-negative staphylococci (CoNS) in neutropenic hematological patients. Sensitivity for samples representing true CoNS-BSIs was 23.3% with an integrated cutoff and increased to 83.3% if the cutoff was neglected. Hence, the cutoff may prohibit timely targeted antimicrobial therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus / Coagulase / Sepse / Neoplasias Hematológicas / Reação em Cadeia da Polimerase Multiplex / Neutropenia Febril Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus / Coagulase / Sepse / Neoplasias Hematológicas / Reação em Cadeia da Polimerase Multiplex / Neutropenia Febril Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article