Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase Î·.

Patra, Amritraj; Su, Yan; Zhang, Qianqian; Johnson, Kevin M; Guengerich, F Peter; Egli, Martin

Patra, Amritraj; Su, Yan; Zhang, Qianqian; Johnson, Kevin M; Guengerich, F Peter; Egli, Martin.

Afiliação

Patra A; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Su Y; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Zhang Q; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Johnson KM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Guengerich FP; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146. Electronic address: f.guengerich@vanderbilt.edu.
Egli M; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146. Electronic address: martin.egli@vanderbilt.edu.

J Biol Chem ; 291(27): 14134-14145, 2016 Jul 01.

Article em En | MEDLINE | ID: mdl-27226627

Assuntos

Adenosina/análogos & derivados; Adenosina/química; Adutos de DNA/química; DNA Polimerase Dirigida por DNA/química; Cristalografia por Raios X; Humanos; Espectrometria de Massas; Estrutura Terciária de Proteína

Palavras-chave

DNA damage; DNA enzyme; DNA polymerase; X-ray crystallography; enzyme kinetics

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenosina / Adutos de DNA / DNA Polimerase Dirigida por DNA Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google