Extension of the serum digoxin concentration--response relationship to patient management.
J Clin Pharmacol
; 29(4): 300-6, 1989 Apr.
Article
em En
| MEDLINE
| ID: mdl-2723118
ABSTRACT
The purposes of this investigation were to demonstrate how computer simulations may be employed to extrapolate data obtained from a single intravenous digoxin dose to multiple oral dosing patterns and how these simulations may apply to clinical situations. The intravenous data were obtained from a previous study of the pharmacokinetics of serum digoxin and its inotropic response (derived from systolic intervals) in 12 normal male volunteers. The simulations were applied to various clinical situations including variations in oral dosing, alternate loading doses, no loading versus loading dose, and intravenous versus oral dosing. A nonlinear relationship was found between response and the post-distribution serum digoxin concentration in the therapeutic range. Thus, the increase in inotropic response is less than proportional to the increase in digoxin concentration in serum. This nonlinear relationship has several important clinical implications for loading and maintenance dosing protocols. Such concepts may be important relative to more rational clinical use of digoxin and to decreasing digoxin toxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Digoxina
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article