Cytokine responses to eye spray adjuvants for enhancing vaccine-induced immunity in chickens.
Microbiol Immunol
; 60(7): 511-5, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-27240729
ABSTRACT
Eye spray influenza vaccines for chickens are increasingly available; however, how to enhance cellular and antibody responses to them remains undetermined. Here, eye-drops containing the immune-enhancing adjuvants Pam2CSK4 or polyIC were assessed in chickens. Application of these TLR agonists to chicken conjunctiva resulted in up-regulation of IL-1ß, but not other cytokines, including IFN and IL-6, in the spleen, lung and Harderian gland. Thus, responses to adjuvant applied to the conjunctival mucosa of chickens differ from those expected from the responses to intra-nasal adjuvants in mammals. Identifying an appropriate delivery route for adjuvants is crucial for evoking immune responses in chickens.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas
/
Galinhas
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Adjuvantes Imunológicos
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Citocinas
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Imunidade
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article