Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression.
Nat Rev Neurosci
; 17(8): 524-32, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27256556
ABSTRACT
The dopamine system is unique among the brain's modulatory systems in that it has discrete projections to specific brain regions involved in motor behaviour, cognition and emotion. Dopamine neurons exhibit several activity patterns - including tonic and phasic firing - that are determined by a combination of endogenous pacemaker conductances and regulation by multiple afferent systems. Emerging evidence suggests that disruptions in these regulatory systems may underlie the pathophysiology of several psychiatric disorders, including schizophrenia and depression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Encéfalo
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Dopamina
/
Depressão
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Transtorno Depressivo
/
Neurônios
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article