Thyroid function and cardiovascular disease risk factors in euthyroid adults: a cross-sectional and longitudinal study.
Clin Endocrinol (Oxf)
; 85(6): 932-941, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-27256825
ABSTRACT
OBJECTIVE AND DESIGN:
We explored the cross-sectional and longitudinal associations of thyroid function within the normal range with cardiovascular disease (CVD) risk factors and adiposity measures. PATIENTS AND MEASUREMENTS A total of 3483 (50·4% women) participants for the cross-sectional CVD study and 1630 (41·2% women) participants for the cross-sectional body composition substudy were drawn from the Framingham Third Generation Exam 1; 2912 participants (50·1% women) for the longitudinal CVD study and 713 participants (35·9% women) for the longitudinal body composition substudy were drawn from the Framingham Third Generation Exams 1-2. Thyroid function was assessed by thyrotropin [thyroid-stimulating hormone (TSH)] and free thyroxine (fT4) concentrations within the reference range at Exam 1. The associations between thyroid function and CVD risk factors were modelled via multivariable-adjusted regression models. Multivariable adjustment included age, sex, current smoking, postmenopausal status and BMI.RESULTS:
Cross-sectionally, higher TSH concentration was associated with increased odds of hypertriglyceridaemia [odds ratio (OR)=1·10], and higher BMI (ß = 0·19 kg/m2 ), total cholesterol (ß = 0·05 mmol/l), triglycerides (ß = 0·0006 mmol/l) and subcutaneous adipose tissue (SAT) volume (ß = 38·8 cm3 ) (all P < 0·05). Cross-sectionally, fT4 was inversely associated with metabolic and adiposity-related CVD risk factors, including obesity (OR = 1·17), hypertriglyceridaemia (OR = 1·09), BMI (ß = 0·42 kg/m2 ), total cholesterol (ß = 0·05 mmol/l), triglycerides (ß = 0·0002 mmol/l), visceral adipose tissue (VAT) volume (ß = -20·7 cm3 ) and attenuation (0·17 HU) and VAT/SAT ratio (ß = -0·01) (all P < 0·05). However, during 6·1 years of follow-up, baseline TSH and fT4 levels were not longitudinally associated with CVD risk factors and adiposity measures.CONCLUSIONS:
Thyroid function within the normal range is cross-sectionally, but not longitudinally, associated with CVD risk factors and adiposity measures.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
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Doenças Cardiovasculares
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article