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A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer.
Kinzel, Linda; Ernst, Anne; Orth, Michael; Albrecht, Valerie; Hennel, Roman; Brix, Nikko; Frey, Benjamin; Gaipl, Udo S; Zuchtriegel, Gabriele; Reichel, Christoph A; Blutke, Andreas; Schilling, Daniela; Multhoff, Gabriele; Li, Minglun; Niyazi, Maximilian; Friedl, Anna A; Winssinger, Nicolas; Belka, Claus; Lauber, Kirsten.
Afiliação
  • Kinzel L; Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Ernst A; Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Orth M; Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Albrecht V; Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Hennel R; Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Brix N; Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Frey B; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
  • Gaipl US; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
  • Zuchtriegel G; Department of Otorhinolaryngology, Head and Neck Surgery, and Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Reichel CA; Department of Otorhinolaryngology, Head and Neck Surgery, and Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Blutke A; Institute of Veterinary Pathology at the Center for Clinical Veterinary Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Schilling D; Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Multhoff G; Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Li M; Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Niyazi M; Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Friedl AA; Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Winssinger N; Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland.
  • Belka C; Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Lauber K; Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich, Germany.
Oncotarget ; 7(28): 43199-43219, 2016 Jul 12.
Article em En | MEDLINE | ID: mdl-27259245
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radiossensibilizantes / Neoplasias Colorretais / Apoptose / Proteínas de Choque Térmico HSP90 / Macrolídeos / Quimiorradioterapia / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radiossensibilizantes / Neoplasias Colorretais / Apoptose / Proteínas de Choque Térmico HSP90 / Macrolídeos / Quimiorradioterapia / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article