Insights into zinc and cadmium biology in the nematode Caenorhabditis elegans.
Arch Biochem Biophys
; 611: 120-133, 2016 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-27261336
ABSTRACT
Zinc is an essential metal that is involved in a wide range of biological processes, and aberrant zinc homeostasis is implicated in multiple human diseases. Cadmium is chemically similar to zinc, but it is a nonessential environmental pollutant. Because zinc deficiency and excess are deleterious, animals require homeostatic mechanisms to maintain zinc levels in response to dietary fluctuations. The nematode Caenorhabditis elegans is emerging as a powerful model system to investigate zinc trafficking and homeostasis as well as cadmium toxicity. Here we review genetic and molecular studies that have combined to generate a picture of zinc homeostasis based on the transcriptional control of zinc transporters in intestinal cells. Furthermore, we summarize studies of cadmium toxicity that reveal intriguing parallels with zinc biology.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zinco
/
Cádmio
/
Caenorhabditis elegans
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article