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OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition.
Ma, Shan-Yao; Ning, Meng-Meng; Zou, Qing-An; Feng, Ying; Ye, Yang-Liang; Shen, Jian-Hua; Leng, Ying.
Afiliação
  • Ma SY; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Ning MM; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Zou QA; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Feng Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Ye YL; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Shen JH; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Leng Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Acta Pharmacol Sin ; 37(10): 1359-1369, 2016 Sep.
Article em En | MEDLINE | ID: mdl-27264313
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinoxalinas / Xantinas / Glicemia / Receptores Acoplados a Proteínas G / Inibidores da Dipeptidil Peptidase IV / Hipoglicemiantes Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinoxalinas / Xantinas / Glicemia / Receptores Acoplados a Proteínas G / Inibidores da Dipeptidil Peptidase IV / Hipoglicemiantes Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article