Knockdown of placental growth factor (PLGF) mitigates hyperoxia-induced acute lung injury in neonatal rats: Suppressive effects on NF&#954;B signaling pathway.

Zhang, Liang; Zhao, Shuang; Yuan, Lijie; Wu, Hongmin; Jiang, Hong; Luo, Gang; Zhao, Shimeng

Knockdown of placental growth factor (PLGF) mitigates hyperoxia-induced acute lung injury in neonatal rats: Suppressive effects on NFκB signaling pathway.

Zhang, Liang; Zhao, Shuang; Yuan, Lijie; Wu, Hongmin; Jiang, Hong; Luo, Gang; Zhao, Shimeng.

Afiliação

Zhang L; Department of Neonatology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, People's Republic of China. Electronic address: lzhang@cmu.edu.cn.
Zhao S; Department of Pediatrics, Shenyang Fourth People's Hospital, Shenyang, Liaoning 110003, People's Republic of China.
Yuan L; Department of Biochemistry and Molecular Biology, Harbin Medical University (Daqing Campus), Daqing, Heilongjiang 163319, People's Republic of China.
Wu H; Department of Neonatology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, People's Republic of China.
Jiang H; Department of Pediatrics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, People's Republic of China.
Luo G; Department of Pediatrics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, People's Republic of China.
Zhao S; Department of Neonatology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, People's Republic of China.

Int Immunopharmacol ; 38: 167-74, 2016 Sep.

Article em En | MEDLINE | ID: mdl-27280587

Assuntos

Lesão Pulmonar Aguda/metabolismo; Células Epiteliais/fisiologia; Hiperóxia/metabolismo; Pulmão/patologia; Fator de Crescimento Placentário/metabolismo; Animais; Animais Recém-Nascidos; Linhagem Celular; Citocinas/metabolismo; Células Epiteliais/efeitos dos fármacos; Feminino; Masculino; Metaloproteinase 2 da Matriz/genética; Metaloproteinase 2 da Matriz/metabolismo; Metaloproteinase 9 da Matriz/genética; Metaloproteinase 9 da Matriz/metabolismo; NF-kappa B/antagonistas & inibidores; Fator de Crescimento Placentário/genética; Pirrolidinas/farmacologia; RNA Interferente Pequeno/genética; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética; Superóxido Dismutase/metabolismo; Tiocarbamatos/farmacologia

Palavras-chave

ALI; Hyperoxia; Inflammation; NFκB signaling pathway; Oxidative stress damage; PLGF

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperóxia / Células Epiteliais / Lesão Pulmonar Aguda / Fator de Crescimento Placentário / Pulmão Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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