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Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis.
Davis, Holly J; Kavanagh, Madeline E; Balan, Tudor; Abell, Chris; Coyne, Anthony G.
Afiliação
  • Davis HJ; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
  • Kavanagh ME; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
  • Balan T; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
  • Abell C; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
  • Coyne AG; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom. Electronic address: agc40@cam.ac.uk.
Bioorg Med Chem Lett ; 26(15): 3735-40, 2016 08 01.
Article em En | MEDLINE | ID: mdl-27287372
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Sistema Enzimático do Citocromo P-450 / Inibidores das Enzimas do Citocromo P-450 / Indóis / Mycobacterium tuberculosis Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Sistema Enzimático do Citocromo P-450 / Inibidores das Enzimas do Citocromo P-450 / Indóis / Mycobacterium tuberculosis Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article