The evaluation of ß-(1 â 3)-nonaglucoside as an anti-Candida albicans immune response inducer.
Cell Microbiol
; 18(9): 1294-307, 2016 09.
Article
em En
| MEDLINE
| ID: mdl-27310441
ABSTRACT
Synthetically prepared bovine serum albumin (BSA) conjugate of linear ß-(1 â 3)-nonaglucoside ligand (G9) has been applied as a biological response immunomodulator in vivo and ex vivo. Active immunization of Balb/c mice revealed effective induction of specific humoral responses in comparison with Candida ß-D-glucan and Candida whole cells. Induced post-vaccination serum exhibited a growth-inhibition effect on the multi-azole-resistant clinical strain Candida albicans CCY 29-3-164 in experimental mucocutaneous infection ex vivo. Evaluation of immune cell proliferation and the cytotoxic potential of the G9-ligand has revealed its bioavailability and an immunostimulative effect in vaccination-sensitized Balb/c mice splenocytes and RAW 264.7 macrophages.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Candida albicans
/
Candidíase
/
Polissacarídeos Fúngicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article