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Regulation of retinal angiogenesis by phospholipase C-ß3 signaling pathway.
Ha, Jung Min; Baek, Seung Hoon; Kim, Young Hwan; Jin, Seo Yeon; Lee, Hye Sun; Kim, Sun Ja; Shin, Hwa Kyoung; Lee, Dong Hyung; Song, Sang Heon; Kim, Chi Dae; Bae, Sun Sik.
Afiliação
  • Ha JM; Department of Pharmacology, Gene and Cell Therapy Center for Vessel-Associated Disease, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Baek SH; Department of Anesthesia and Pain Medicine, Pusan National University Hospital, Yangsan, Republic of Korea.
  • Kim YH; Department of Pharmacology, Gene and Cell Therapy Center for Vessel-Associated Disease, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Jin SY; Department of Pharmacology, Gene and Cell Therapy Center for Vessel-Associated Disease, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Lee HS; Department of Pharmacology, Gene and Cell Therapy Center for Vessel-Associated Disease, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Kim SJ; Department of Physics, Dong-A University, Busan, Republic of Korea.
  • Shin HK; Department of Anatomy, Pusan National University of Korean Medicine, Yangsan, Republic of Korea.
  • Lee DH; Department of Obstetrics and Gynecology, Pusan National University Hospital, Yangsan, Republic of Korea.
  • Song SH; Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea.
  • Kim CD; Department of Pharmacology, Gene and Cell Therapy Center for Vessel-Associated Disease, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Bae SS; Department of Pharmacology, Gene and Cell Therapy Center for Vessel-Associated Disease, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Exp Mol Med ; 48(6): e240, 2016 06 17.
Article em En | MEDLINE | ID: mdl-27311705
ABSTRACT
Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-ß3 (PLC-ß3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-ß3 in human umbilical vein endothelial cells (HUVECs) significantly delayed proliferation, migration and capillary-like tube formation. In addition, mice lacking PLC-ß3 showed impaired retinal angiogenesis with delayed endothelial proliferation, reduced endothelial cell activation, abnormal vessel formation and hemorrhage. Finally, tumor formation was significantly reduced in mice lacking PLC-ß3 and showed irregular size and shape of blood vessels. These results suggest that regulation of endothelial function by PLC-ß3 may contribute to angiogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasos Retinianos / Transdução de Sinais / Neovascularização Fisiológica / Fosfolipase C beta Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasos Retinianos / Transdução de Sinais / Neovascularização Fisiológica / Fosfolipase C beta Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article