Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPK&#945; Signalling Pathway.

Ma, Zhen-Guo; Dai, Jia; Wei, Wen-Ying; Zhang, Wen-Bin; Xu, Si-Chi; Liao, Hai-Han; Yang, Zheng; Tang, Qi-Zhu

Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway.

Ma, Zhen-Guo; Dai, Jia; Wei, Wen-Ying; Zhang, Wen-Bin; Xu, Si-Chi; Liao, Hai-Han; Yang, Zheng; Tang, Qi-Zhu.

Afiliação

Ma ZG; 1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China;; 2. Cardiovascular Research Institute of Wuhan University, Wuhan, China.
Dai J; 1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China;; 2. Cardiovascular Research Institute of Wuhan University, Wuhan, China.
Wei WY; 1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China;; 2. Cardiovascular Research Institute of Wuhan University, Wuhan, China.
Zhang WB; 1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China;; 2. Cardiovascular Research Institute of Wuhan University, Wuhan, China.
Xu SC; 1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China;; 2. Cardiovascular Research Institute of Wuhan University, Wuhan, China.
Liao HH; 1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China;; 2. Cardiovascular Research Institute of Wuhan University, Wuhan, China.
Yang Z; 1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China;; 2. Cardiovascular Research Institute of Wuhan University, Wuhan, China.
Tang QZ; 1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China;; 2. Cardiovascular Research Institute of Wuhan University, Wuhan, China.

Int J Biol Sci ; 12(7): 861-71, 2016.

Article em En | MEDLINE | ID: mdl-27313499

Assuntos

Proteínas Quinases Ativadas por AMP/metabolismo; Cardiomegalia/tratamento farmacológico; Cardiomegalia/metabolismo; Triterpenos Pentacíclicos/farmacologia; Triterpenos Pentacíclicos/uso terapêutico; Proteínas Quinases Ativadas por AMP/genética; Adenoviridae; Animais; Western Blotting; Ecocardiografia; MAP Quinases Reguladas por Sinal Extracelular/genética; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Imunofluorescência; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Fosforilação/efeitos dos fármacos; Reação em Cadeia da Polimerase em Tempo Real; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética; Serina-Treonina Quinases TOR/genética; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

AMPKα; Asiatic acid; Cardiac fibrosis; Cardiac hypertrophy.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomegalia / Triterpenos Pentacíclicos / Proteínas Quinases Ativadas por AMP Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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