Biodegradable microspheres: vaccine delivery system for oral immunization.
Curr Top Microbiol Immunol
; 146: 59-66, 1989.
Article
em En
| MEDLINE
| ID: mdl-2731430
ABSTRACT
The potential of biocompatible and biodegradable microspheres as a controlled release oral vaccine delivery system has been examined. Orally-administered 1-10 micron microspheres composed of poly (DL-lactide-co-glycolide) were specifically taken up into the Peyer's patch lymphoid tissue of the gut, where those greater than or equal to 5 micron remained for up to 35 days. Microspheres less than 5 micron disseminated within macrophages to the mesenteric lymph nodes and spleen. In contrast to soluble staphylococcal enterotoxin B toxoid, oral immunization with enterotoxoid in microspheres induced circulating toxin-specific antibodies and a concurrent secretory IgA anti-toxin response in saliva and gut fluid.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article