Association between matrix metallopeptidase 1 and type 2 diabetes mellitus coexisting with coronary heart disease in a Han Chinese population.
Genet Mol Res
; 15(2)2016 Jun 10.
Article
em En
| MEDLINE
| ID: mdl-27323171
ABSTRACT
Matrix metallopeptidase 1 (MMP-1) has been reported to be involved in the coexistence of type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). We sought to examine the association between the MMP-1 gene polymorphism and coexistence of T2DM and CHD in a Han Chinese population. We extracted genomic DNA from the peripheral blood of 794 subjects, including 378 patients with coexisting T2DM and CHD and 416 healthy controls. We selected several single nucleotide polymorphisms of the MMP-1 gene and genotyped them using the MassARRAY system, before analyzing the data with Haploview 4.0 and SPSS 20.0. A statistical difference was found in the distribution of rs1799750 genotypes between the patient and control groups (P = 0.041). The frequency of the 2G/2G genotype was 44.25 and 37.0% among patients and control subjects, respectively. Moreover, the frequency of the 2G allele was 65.9% among patients and 59.6% in the control group, and this difference was found to be significant (P = 0.010). Elevated body mass index was also associated with the 2G/2G genotype. Thus, MMP-1 rs1799750 may be involved in the development of coexisting T2DM and CHD in the Han Chinese population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença das Coronárias
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Metaloproteinase 1 da Matriz
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Diabetes Mellitus Tipo 2
/
Estudos de Associação Genética
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article