Predictive value of high sensitivity C-reactive protein in the diagnosis and outcomes of acute aortic syndromes.
Heart Asia
; 2(1): 136-9, 2010.
Article
em En
| MEDLINE
| ID: mdl-27325965
ABSTRACT
OBJECTIVE:
The purpose of this study was to determine whether high-sensitivity C-reactive protein (hsCRP) levels differ among patients with acute aortic syndromes (AAS) and if hsCRP could predict their long-term outcomes.DESIGN:
Retrospective observational study.SETTING:
Cleveland Clinic Hospital, Cleveland, Ohio. PATIENTS 115 consecutive patients with AAS admitted to the cardiac intensive care unit.INTERVENTIONS:
HsCRP and other laboratory data were measured within 24â h of admission. Demographic, imaging and laboratory data were obtained at the time of presentation. For the long-term survival analysis, the social security death index was used to determine all-cause mortality. MAIN OUTCOMEMEASURES:
HsCRP levels among AAS patients.RESULTS:
Hospital mortality was 4.3% for AAS patients. HsCRP levels differed significantly among AAS; the median hsCRP was higher in the aortic dissection group (49â mg/l) than in those with penetrating aortic ulcer (28â mg/l), symptomatic aortic aneurysm (14â mg/l), and intramural haematoma (10â mg/l); (p=0.02). In multivariable analysis, aortic dissection patients had higher hsCRP levels than intramural haematoma (p=0.03) and symptomatic aortic aneurysm (p=0.04) patients, after adjusting for age and gender. Multivariable Cox regression analyses showed that elevated hsCRP levels at presentation were associated with a higher long-term mortality (p=0.007).CONCLUSIONS:
Among patients with AAS, those with aortic dissection have the highest hsCRP levels at presentation. Elevated hsCRP independently predicted a higher long-term mortality in AAS patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article