Bio-nano interactions detected by nanochannel electrophoresis.
Electrophoresis
; 37(15-16): 2190-5, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27334561
ABSTRACT
Engineered nanoparticles have been widely used in industry and are present in many consumer products. However, their bio-safeties especially in a long term are largely unknown. Here, a nanochannel-electrophoresis-based method is proposed for detecting the potential bio-nano interactions that may further lead to damages to human health and/or biological environment. Through proof-of-concept molecular dynamics simulations, it was demonstrated that the transport of a protein-nanoparticle complex is very different from that of a protein along. By monitoring the change of ionic currents induced by a transported analyte as well as the transport velocities of the analyte, the complex (with bio-nano interaction) can be clearly distinguished from the protein alone (with no interaction with tested nanoparticles).
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Nanoestruturas
/
Eletroforese
/
Nanopartículas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article