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Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.
Godoy, Patricio; Widera, Agata; Schmidt-Heck, Wolfgang; Campos, Gisela; Meyer, Christoph; Cadenas, Cristina; Reif, Raymond; Stöber, Regina; Hammad, Seddik; Pütter, Larissa; Gianmoena, Kathrin; Marchan, Rosemarie; Ghallab, Ahmed; Edlund, Karolina; Nüssler, Andreas; Thasler, Wolfgang E; Damm, Georg; Seehofer, Daniel; Weiss, Thomas S; Dirsch, Olaf; Dahmen, Uta; Gebhardt, Rolf; Chaudhari, Umesh; Meganathan, Kesavan; Sachinidis, Agapios; Kelm, Jens; Hofmann, Ute; Zahedi, René P; Guthke, Reinhard; Blüthgen, Nils; Dooley, Steven; Hengstler, Jan G.
Afiliação
  • Godoy P; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany. godoy@ifado.de.
  • Widera A; Facultad de Ciencias Biológicas, Departamento de Fisiología, Universidad de Concepción, Concepción, Chile. godoy@ifado.de.
  • Schmidt-Heck W; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.
  • Campos G; Leibniz Institute for Natural Product Research and Infection Biology eV-Hans-Knöll Institute, Jena, Germany.
  • Meyer C; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.
  • Cadenas C; Molecular Alcohol Research in Gastroenterology, Department of Medicine II, Faculty of Medicine at Mannheim, University of Heidelberg, Mannheim, Germany.
  • Reif R; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.
  • Stöber R; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.
  • Hammad S; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.
  • Pütter L; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.
  • Gianmoena K; Molecular Alcohol Research in Gastroenterology, Department of Medicine II, Faculty of Medicine at Mannheim, University of Heidelberg, Mannheim, Germany.
  • Marchan R; Department of Forensic and Veterinary Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
  • Ghallab A; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.
  • Edlund K; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.
  • Nüssler A; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.
  • Thasler WE; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.
  • Damm G; Department of Forensic and Veterinary Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
  • Seehofer D; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.
  • Weiss TS; BG Trauma Center, Siegfrid Weller Insitut, Eberhard Karls University Tübingen, Tübingen, Germany.
  • Dirsch O; Center for Liver Cell Research, Department of General, Visceral, Transplantation, Vascular and Thorax Surgery, Grosshadern Hospital, Ludwig Maximilians University, Munich, Germany.
  • Dahmen U; Department of General, Visceral and Transplantation Surgery, Charité University Medicine Berlin, Berlin, Germany.
  • Gebhardt R; Department of General, Visceral and Transplantation Surgery, Charité University Medicine Berlin, Berlin, Germany.
  • Chaudhari U; Center for Liver Cell Research, University Children Hospital (KUNO), Regensburg University Hospital, Regensburg, Germany.
  • Meganathan K; Institute of Pathology, Friedrich-Schiller-University of Jena, Jena, Germany.
  • Sachinidis A; Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, University Hospital Jena, Friedrich-Schiller-University of Jena, Jena, Germany.
  • Kelm J; Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
  • Hofmann U; Institute of Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.
  • Zahedi RP; Institute of Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.
  • Guthke R; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
  • Blüthgen N; Institute of Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.
  • Dooley S; InSphero AG, Wagistrasse 27, 8952, Schlieren, Switzerland.
  • Hengstler JG; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tuebingen, Auerbachstrasse 112, 70376, Stuttgart, Germany.
Arch Toxicol ; 90(10): 2513-29, 2016 Oct.
Article em En | MEDLINE | ID: mdl-27339419
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatócitos / Redes Reguladoras de Genes / Cultura Primária de Células / Transcriptoma / Hepatopatias Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatócitos / Redes Reguladoras de Genes / Cultura Primária de Células / Transcriptoma / Hepatopatias Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article