Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.

Temple, Kayla J; Wright, Elia N; Fierke, Carol A; Gibbs, Richard A

Temple, Kayla J; Wright, Elia N; Fierke, Carol A; Gibbs, Richard A.

Afiliação

Temple KJ; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA; The Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47909, USA. Electronic address: kayla.temple@vanderbilt.edu.
Wright EN; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Fierke CA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Gibbs RA; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA; The Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47909, USA.

Bioorg Med Chem Lett ; 26(15): 3503-7, 2016 08 01.

Article em En | MEDLINE | ID: mdl-27342751

Assuntos

Alquil e Aril Transferases/antagonistas & inibidores; Fosfatos de Poli-Isoprenil/síntese química; Fosfatos de Poli-Isoprenil/farmacologia; Alquil e Aril Transferases/metabolismo; Relação Dose-Resposta a Droga; Humanos; Estrutura Molecular; Fosfatos de Poli-Isoprenil/química; Relação Estrutura-Atividade

Palavras-chave

Farnesylation; Geranylgeranylation; Isoprenoid synthesis; Protein prenylation; Saturated GGPP analogs

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos de Poli-Isoprenil / Alquil e Aril Transferases Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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