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Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.
Chen, Kuchuan; Lin, Guang; Haelterman, Nele A; Ho, Tammy Szu-Yu; Li, Tongchao; Li, Zhihong; Duraine, Lita; Graham, Brett H; Jaiswal, Manish; Yamamoto, Shinya; Rasband, Matthew N; Bellen, Hugo J.
Afiliação
  • Chen K; Program in Developmental Biology, Baylor College of Medicine, Houston, United States.
  • Lin G; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
  • Haelterman NA; Program in Developmental Biology, Baylor College of Medicine, Houston, United States.
  • Ho TS; Department of Neuroscience, Baylor College of Medicine, Houston, United States.
  • Li T; Program in Developmental Biology, Baylor College of Medicine, Houston, United States.
  • Li Z; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
  • Duraine L; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, United States.
  • Graham BH; Program in Developmental Biology, Baylor College of Medicine, Houston, United States.
  • Jaiswal M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
  • Yamamoto S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
  • Rasband MN; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, United States.
  • Bellen HJ; Program in Developmental Biology, Baylor College of Medicine, Houston, United States.
Elife ; 52016 06 25.
Article em En | MEDLINE | ID: mdl-27343351
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esfingolipídeos / Ataxia de Friedreich / Fatores de Regulação Miogênica / Proteínas de Drosophila / Proteínas de Ligação ao Ferro / Proteínas Quinases Dependentes de 3-Fosfoinositídeo / Ferro Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esfingolipídeos / Ataxia de Friedreich / Fatores de Regulação Miogênica / Proteínas de Drosophila / Proteínas de Ligação ao Ferro / Proteínas Quinases Dependentes de 3-Fosfoinositídeo / Ferro Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article