Rosmarinic acid protects against chronic ethanol-induced learning and memory deficits in rats.
Nutr Neurosci
; 20(9): 547-554, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-27367870
ABSTRACT
OBJECTIVES:
Ethanol consumption induces neurological disorders including cognitive dysfunction. Oxidative damage is considered a likely cause of cognitive deficits. We aimed to investigate the effects of rosmarinic acid (RA) in different doses for 30 days on chronic ethanol-induced cognitive dysfunction using the passive avoidance learning (PAL) and memory task in comparison with donepezil, a reference drug. We also evaluated the levels of superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation in hippocampus as possible mechanisms.METHODS:
Memory impairment was induced by 15%â w/v ethanol (2 g/kg, i.g.) administration for 30 days. RA (8, 16, and 32â mg/kg, i.g.) or donepezil (2â mg/kg, i.g.) was administered 30 minutes before ethanol. The acquisition trial was done 1â hour after the last administration of RA and donepezil. At the end, animals were weighed and hippocami were isolated for analyzing of oxidant/antioxidant markers.RESULTS:
Ethanol caused cognition deficits in the PAL and memory task. While RA 16 and 32â mg/kg improved cognition in control rats, it prevented learning and memory deficits of alcoholic groups. RA 8â mg/kg did not influence cognitive function in both control and alcoholic rats. RA 32â mg/kg had comparable effects with donepezil in prevention of acquisition and retention memory impairment. The higher doses of RA not only prevented increased lipid peroxidation and nitrite content but also decreased SOD, CAT, GSH, and FRAP levels in alcoholic groups and exerted antioxidant effects in non-alcoholic rats.DISCUSSION:
We showed that RA administration dose-dependently prevented cognitive impairment induced by chronic ethanol in PAL and memory and disturbed oxidant/antioxidant status as a possible mechanism. The antioxidant, anticholinesterase, and neuroprotective properties of RA may be involved in the observed effects. Therefore, RA represents a potential therapeutic option against chronic ethanol-induced amnesia which deserves consideration and further examination.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cinamatos
/
Nootrópicos
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Suplementos Nutricionais
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Transtornos do Sistema Nervoso Induzidos por Álcool
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Depsídeos
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Deficiências da Aprendizagem
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Transtornos da Memória
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Antioxidantes
Tipo de estudo:
Etiology_studies
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article