Untargeted mass spectrometric approach in metabolic healthy offspring of patients with type 2 diabetes reveals medium-chain acylcarnitine as potential biomarker for lipid induced glucose intolerance (LGIT).

Knebel, Birgit; Mack, Susanne; Lehr, Stefan; Barsch, Aiko; Schiller, Martina; Haas, Jutta; Lange, Simone; Fuchser, Jens; Zurek, Gabriela; Müller-Wieland, Dirk; Kotzka, Jorg

Knebel, Birgit; Mack, Susanne; Lehr, Stefan; Barsch, Aiko; Schiller, Martina; Haas, Jutta; Lange, Simone; Fuchser, Jens; Zurek, Gabriela; Müller-Wieland, Dirk; Kotzka, Jorg.

Afiliação

Knebel B; a Leibniz Center for Diabetes Research, Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf , Düsseldorf , Germany.
Mack S; b German Center for Diabetes Research (DZD), Muenchen-Neuherberg , Germany.
Lehr S; c Institute for Diabetes Research, Department of General Internal Medicine, Asklepios Klinik St. Georg, Medical Faculty of Semmelweis University , Hamburg , Germany , and.
Barsch A; a Leibniz Center for Diabetes Research, Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf , Düsseldorf , Germany.
Schiller M; b German Center for Diabetes Research (DZD), Muenchen-Neuherberg , Germany.
Haas J; d Bruker Daltonik GmbH , Bremen , Germany , and.
Lange S; a Leibniz Center for Diabetes Research, Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf , Düsseldorf , Germany.
Fuchser J; b German Center for Diabetes Research (DZD), Muenchen-Neuherberg , Germany.
Zurek G; c Institute for Diabetes Research, Department of General Internal Medicine, Asklepios Klinik St. Georg, Medical Faculty of Semmelweis University , Hamburg , Germany , and.
Müller-Wieland D; c Institute for Diabetes Research, Department of General Internal Medicine, Asklepios Klinik St. Georg, Medical Faculty of Semmelweis University , Hamburg , Germany , and.
Kotzka J; d Bruker Daltonik GmbH , Bremen , Germany , and.

Arch Physiol Biochem ; 122(5): 266-280, 2016 Dec.

Article em En | MEDLINE | ID: mdl-27373781

Assuntos

Biomarcadores/metabolismo; Glicemia/metabolismo; Carnitina/análogos & derivados; Diabetes Mellitus Tipo 2/complicações; Intolerância à Glucose/diagnóstico; Lipídeos/efeitos adversos; Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos; Adolescente; Adulto; Idoso; Carnitina/metabolismo; Estudos de Casos e Controles; Cromatografia Líquida; Diabetes Mellitus Tipo 2/fisiopatologia; Feminino; Intolerância à Glucose/etiologia; Intolerância à Glucose/metabolismo; Teste de Tolerância a Glucose; Humanos; Masculino; Espectrometria de Massas; Metaboloma; Pessoa de Meia-Idade; Adulto Jovem

Palavras-chave

Healthy first degree T2D relatives; metabolic challenging; untargeted metabolome analyses

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Biomarcadores / Carnitina / Intolerância à Glucose / Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz / Diabetes Mellitus Tipo 2 / Lipídeos Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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