Antisense antimicrobial therapeutics.
Curr Opin Microbiol
; 33: 47-55, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27375107
ABSTRACT
Antisense antimicrobial therapeutics are synthetic oligomers that silence expression of specific genes. This specificity confers an advantage over broad-spectrum antibiotics by avoiding unintended effects on commensal bacteria. The sequence-specificity and short length of antisense antimicrobials also pose little risk to human gene expression. Because antisense antimicrobials are a platform technology, they can be rapidly designed and synthesized to target almost any microbe. This reduces drug discovery time, and provides flexibility and a rational approach to drug development. Recent work has shown that antisense technology has the potential to address the antibiotic-resistance crisis, since resistance mechanisms for standard antibiotics apparently have no effect on antisense antimicrobials. Here, we describe current reports of antisense antimicrobials targeted against viruses, parasites, and bacteria.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Parasitárias
/
Infecções Bacterianas
/
Viroses
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Oligodesoxirribonucleotídeos Antissenso
/
Oligorribonucleotídeos Antissenso
/
Oligonucleotídeos Fosforotioatos
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article