Conditional ablation of TGF-ß signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model.
Sci Rep
; 6: 29479, 2016 07 05.
Article
em En
| MEDLINE
| ID: mdl-27378170
ABSTRACT
The role of transforming growth factor-ß (TGF-ß) signaling in cancer progression is still under debate. To determine the function of TGF-ß signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We found the ablation of TGF-ß signaling could inhibit the cancer cell proliferation, cancer stem cell population and EMT, hence suppressed the invasive cancer progression, which is similar with the result of TGF-ß receptor I inhibitor treatment. These findings recognize the roles and mechanisms of TGF-ß signaling in bladder cancer progression in vivo for the first time.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
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Proteínas Serina-Treonina Quinases
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Receptores de Fatores de Crescimento Transformadores beta
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Progressão da Doença
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Fator de Crescimento Transformador beta1
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article