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Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy.
Yan, Min; Wang, Chunli; He, Bin; Yang, Mengying; Tong, Mengying; Long, Zijie; Liu, Bing; Peng, Fei; Xu, Lingzhi; Zhang, Yan; Liang, Dapeng; Lei, Haixin; Subrata, Sen; Kelley, Keith W; Lam, Eric W-F; Jin, Bilian; Liu, Quentin.
Afiliação
  • Yan M; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.
  • Wang C; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • He B; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
  • Yang M; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.
  • Tong M; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
  • Long Z; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
  • Liu B; Institute of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Peng F; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
  • Xu L; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
  • Zhang Y; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
  • Liang D; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.
  • Lei H; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
  • Subrata S; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
  • Kelley KW; Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Lam EW; Laboratory of Immunophysiology, Department of Animal Sciences, College of ACES, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Jin B; Department of Pathology, College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Liu Q; Department of Surgery and Cancer, Imperial College London, London, UK.
Med Res Rev ; 36(6): 1036-1079, 2016 11.
Article em En | MEDLINE | ID: mdl-27406026
The Aurora kinase family is comprised of three serine/threonine kinases, Aurora-A, Aurora-B, and Aurora-C. Among these, Aurora-A and Aurora-B play central roles in mitosis, whereas Aurora-C executes unique roles in meiosis. Overexpression or gene amplification of Aurora kinases has been reported in a broad range of human malignancies, pointing to their role as potent oncogenes in tumorigenesis. Aurora kinases therefore represent promising targets for anticancer therapeutics. A number of Aurora kinase inhibitors (AKIs) have been generated; some of which are currently undergoing clinical evaluation. Recent studies have unveiled novel unexpected functions of Aurora kinases during cancer development and the mechanisms underlying the anticancer actions of AKIs. In this review, we discuss the most recent advances in Aurora-A kinase research and targeted cancer therapy, focusing on the oncogenic roles and signaling pathways of Aurora-A kinases in promoting tumorigenesis, the recent preclinical and clinical AKI data, and potential alternative routes for Aurora-A kinase inhibition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Aurora Quinase A / Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Aurora Quinase A / Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article