Human cytomegalovirus miR-UL112-1 promotes the down-regulation of viral immediate early-gene expression during latency to prevent T-cell recognition of latently infected cells.

Lau, Betty; Poole, Emma; Van Damme, Ellen; Bunkens, Lieve; Sowash, Madeleine; King, Harry; Murphy, Eain; Wills, Mark; Van Loock, Marnix; Sinclair, John

Lau, Betty; Poole, Emma; Van Damme, Ellen; Bunkens, Lieve; Sowash, Madeleine; King, Harry; Murphy, Eain; Wills, Mark; Van Loock, Marnix; Sinclair, John.

Afiliação

Lau B; Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Poole E; Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Van Damme E; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
Bunkens L; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
Sowash M; Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
King H; Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Murphy E; Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Wills M; Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Van Loock M; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
Sinclair J; Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.

J Gen Virol ; 97(9): 2387-2398, 2016 09.

Article em En | MEDLINE | ID: mdl-27411311

Assuntos

Citomegalovirus/genética; Regulação Viral da Expressão Gênica; Expressão Gênica; Genes Precoces; Evasão da Resposta Imune; MicroRNAs/metabolismo; Latência Viral; Células Cultivadas; Citomegalovirus/imunologia; Citomegalovirus/fisiologia; Regulação para Baixo; Humanos; Proteínas Imediatamente Precoces/biossíntese; Proteínas Imediatamente Precoces/genética; Monócitos/virologia; Linfócitos T Citotóxicos/imunologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Expressão Gênica / Regulação Viral da Expressão Gênica / Latência Viral / Genes Precoces / Citomegalovirus / MicroRNAs / Evasão da Resposta Imune Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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