Digoxin is a selective modifier increasing platinum drug anticancer activity.
Dokl Biochem Biophys
; 468(1): 220-3, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-27417726
ABSTRACT
Using the model of breast cancer Ehrlich ascites tumor in mice, we showed that a sigle intraperitoneal injection of cardiac glycoside digoxin 1 h before the intraperitoneal injection of cisplatin increased the anticancer effect of the cytostatic drug more than twice when recalculated for the dose. It is assumed that the modifying effect of digoxin is determined by the direct inhibition of glycolysis in tumor cells. Taking into account the design of the study, we consider promising the clinical evaluation of the effectiveness of digoxin as a modifier of cisplatin efficiency in intracavitary therapy of ascites cancers with pleural and abdominal dissenmination.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Carcinoma de Ehrlich
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Cisplatino
/
Digoxina
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Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article