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Diagnostic potential of tumor DNA from ovarian cyst fluid.
Wang, Yuxuan; Sundfeldt, Karin; Mateoiu, Constantina; Shih, Ie-Ming; Kurman, Robert J; Schaefer, Joy; Silliman, Natalie; Kinde, Isaac; Springer, Simeon; Foote, Michael; Kristjansdottir, Björg; James, Nathan; Kinzler, Kenneth W; Papadopoulos, Nickolas; Diaz, Luis A; Vogelstein, Bert.
Afiliação
  • Wang Y; Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States.
  • Sundfeldt K; Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States.
  • Mateoiu C; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden.
  • Shih IeM; Department of Pathology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
  • Kurman RJ; Department of Pathology, The Johns Hopkins Medical Institutes, Baltimore, United States.
  • Schaefer J; Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, United States.
  • Silliman N; Department of Pathology, The Johns Hopkins Medical Institutes, Baltimore, United States.
  • Kinde I; Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, United States.
  • Springer S; Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States.
  • Foote M; Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States.
  • Kristjansdottir B; Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States.
  • James N; Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States.
  • Kinzler KW; Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States.
  • Papadopoulos N; Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States.
  • Diaz LA; Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States.
  • Vogelstein B; Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States.
Elife ; 52016 07 15.
Article em En | MEDLINE | ID: mdl-27421040
ABSTRACT
We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were found in the cyst fluids of 18 patients with benign tumors or non-neoplastic cysts. Though large, prospective studies are needed to demonstrate the safety and clinical utility of this approach, our results suggest that the genetic evaluation of cyst fluids might be able to inform the management of the large number of women with these lesions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cistos Ovarianos / Neoplasias Ovarianas / DNA / Líquido Cístico / Mutação Tipo de estudo: Diagnostic_studies / Evaluation_studies / Observational_studies / Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cistos Ovarianos / Neoplasias Ovarianas / DNA / Líquido Cístico / Mutação Tipo de estudo: Diagnostic_studies / Evaluation_studies / Observational_studies / Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article