Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease.

Kamphuis, Willem; Kooijman, Lieneke; Schetters, Sjoerd; Orre, Marie; Hol, Elly M

Kamphuis, Willem; Kooijman, Lieneke; Schetters, Sjoerd; Orre, Marie; Hol, Elly M.

Afiliação

Kamphuis W; Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands. Electronic address: w.kamphuis@nin.knaw.nl.
Kooijman L; Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands; Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, The Netherlands.
Schetters S; Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Orre M; Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands; Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
Hol EM; Astrocyte Biology & Neurodegeneration, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands; Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, The Netherlands; Departme

Biochim Biophys Acta ; 1862(10): 1847-60, 2016 10.

Article em En | MEDLINE | ID: mdl-27425031

Assuntos

Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Antígeno CD11c/metabolismo; Regulação da Expressão Gênica; Microglia/metabolismo; Proteínas do Tecido Nervoso/biossíntese; Doença de Alzheimer/genética; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/genética; Animais; Antígeno CD11c/genética; Modelos Animais de Doenças; Perfilação da Expressão Gênica; Camundongos; Camundongos Transgênicos; Microglia/patologia; Proteínas do Tecido Nervoso/genética

Palavras-chave

Aß; CD11C; CD11b; Gene expression; Inflammation; Microglia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Peptídeos beta-Amiloides / Microglia / Antígeno CD11c / Doença de Alzheimer / Proteínas do Tecido Nervoso Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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