Implementation of a management protocol for massive bleeding reduces mortality in non-trauma patients: Results from a single centre audit.
Med Intensiva
; 40(9): 550-559, 2016 Dec.
Article
em En, Es
| MEDLINE
| ID: mdl-27425576
ABSTRACT
OBJECTIVE:
To audit the impact upon mortality of a massive bleeding management protocol (MBP) implemented in our center since 2007.DESIGN:
A retrospective, single-center study was carried out. Patients transfused after MBP implementation (2007-2012, Group 2) were compared with a historical cohort (2005-2006, Group 1).BACKGROUND:
Massive bleeding is associated to high mortality rates. Available MBPs are designed for trauma patients, whereas specific recommendations in the medical/surgical settings are scarce. PATIENTS After excluding patients who died shortly (<6h) after MBP activation (n=20), a total of 304 were included in the data analysis (68% males, 87% surgical).INTERVENTIONS:
Our MBP featured goal-directed transfusion with early use of adjuvant hemostatic medications. VARIABLES OF INTEREST Primary endpoints were 24-h and 30-day mortality. Fresh frozen plasma-to-red blood cells (FFPRBC) and platelet-to-RBC (PLTRBC) transfusion ratios, time to first FFP unit and the proactive MBP triggering rate were secondary endpoints.RESULTS:
After MBP implementation (Group 2; n=222), RBC use remained stable, whereas FFP and hemostatic agents increased, when compared with Group 1 (n=82). Increased FFPRBC ratio (p=0.053) and earlier administration of FFP (p=0.001) were also observed, especially with proactive MBP triggering. Group 2 patients presented lower rates of 24-h (0.5% vs. 7.3%; p=0.002) and 30-day mortality (15.9% vs. 30.2%; p=0.018) - the greatest reduction corresponding to non-surgical patients. Logistic regression showed an independent protective effect of MBP implementation upon 30-day mortality (OR=0.3; 95% CI 0.15-0.61).CONCLUSIONS:
These data suggest that the implementation of a goal-directed MBP for prompt and aggressive management of non-trauma, massive bleeding patients is associated to reduced 24-h and 30-day mortality rates.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transfusão de Sangue
/
Hemorragia
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
/
Es
Ano de publicação:
2016
Tipo de documento:
Article