Your browser doesn't support javascript.
loading
Involvement of the IL-1 system in experimental autoimmune encephalomyelitis and multiple sclerosis: Breaking the vicious cycle between IL-1ß and GM-CSF.
Paré, Alexandre; Mailhot, Benoit; Lévesque, Sébastien A; Lacroix, Steve.
Afiliação
  • Paré A; Centre de recherche du Centre hospitalier universitaire (CHU) de Québec - Université Laval, and Département de médecine moléculaire, Faculté de médecine, Université Laval, Québec, QC, Canada.
  • Mailhot B; Centre de recherche du Centre hospitalier universitaire (CHU) de Québec - Université Laval, and Département de médecine moléculaire, Faculté de médecine, Université Laval, Québec, QC, Canada.
  • Lévesque SA; Centre de recherche du Centre hospitalier universitaire (CHU) de Québec - Université Laval, and Département de médecine moléculaire, Faculté de médecine, Université Laval, Québec, QC, Canada.
  • Lacroix S; Centre de recherche du Centre hospitalier universitaire (CHU) de Québec - Université Laval, and Département de médecine moléculaire, Faculté de médecine, Université Laval, Québec, QC, Canada. Electronic address: Steve.Lacroix@crchul.ulaval.ca.
Brain Behav Immun ; 62: 1-8, 2017 May.
Article em En | MEDLINE | ID: mdl-27432634
Multiple sclerosis (MS) is an autoimmune disease that affects hundreds of thousands of people worldwide. Given the autoimmune nature of the disease, a large part of the research has focused on autoreactive T and B cells. However, research on the involvement of myeloid cells in the pathophysiology of MS has received a strong and renewed attention over the recent years. Despite the multitude of inflammatory mediators involved in innate immunity, only a select group of cytokines are absolutely critical to the development of CNS autoimmunity, among which is interleukin (IL)-1. While the importance of the IL-1 system in experimental autoimmune encephalomyelitis (EAE) and MS has been recognized for about 20years, it is only recently that we have begun to understand that IL-1 plays multifaceted roles in disease initiation, development, amplification and chronicity. Here, we review the recent findings showing an implication of the IL-1 system in EAE and MS, and introduce a model that highlights how IL-1ß and granulocyte-macrophage colony-stimulating factor (GM-CSF) are interacting together to create a vicious feedback cycle of CNS inflammation that ultimately leads to myelin and neuronal damage.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Estimulador de Colônias de Granulócitos e Macrófagos / Interleucina-1 / Encefalomielite Autoimune Experimental / Esclerose Múltipla Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Estimulador de Colônias de Granulócitos e Macrófagos / Interleucina-1 / Encefalomielite Autoimune Experimental / Esclerose Múltipla Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article