Association of obesity and overweight with the prevalence of insulin resistance, pre-diabetes and clinical-biochemical characteristics among infertile Mexican women with polycystic ovary syndrome: a cross-sectional study.
BMJ Open
; 6(7): e012107, 2016 07 22.
Article
em En
| MEDLINE
| ID: mdl-27449893
ABSTRACT
OBJECTIVE:
To study the association of obesity and overweight with the prevalence of insulin resistance (IR), pre-diabetes and clinical-biochemical characteristics among infertile Mexican women with polycystic ovary syndrome (PCOS).DESIGN:
Retrospective cross-sectional study.SETTING:
Level-three medical institution, an infertility clinic in Mexico City.PARTICIPANTS:
We included infertile Mexican women with diagnosis of PCOS according to the Rotterdam criteria group 1 (n=83), normal weight (body mass index (BMI) 18.5-24.9â kg/m(2)); group 2 (n=217), overweight (BMI 25-29.9â kg/m(2)); and group 3 (n=238), obese (BMI≥30â kg/m(2)). PRIMARY AND SECONDARY OUTCOMEMEASURES:
IR was determined by homeostatic model assessment (HOMA) >2.5 and pre-diabetes by fasting glucose between 5.6 and 6.9â mmol/L and/or glucose value between 7.8 and 11â mmol/L at 2â hours during an oral glucose tolerance test. We compared clinical-biochemical characteristics among groups.RESULTS:
Prevalence of IR for groups 1, 2 and 3 was 19.3%, 56.2% and 78.2%; overweight and obesity increase the IR OR (CI 95%) to 5.3 (2.9 to 9.8) and 14.9 (8.0 to 28), respectively. Prevalence of pre-diabetes for groups 1, 2 and 3 was 7.2%, 17.5% and 31.5%; overweight and obesity increase the pre-diabetes OR (CI 95%) to 2.7 (1.1 to 6.7) and 5.9 (2.4 to 14), respectively. Acanthosis nigricans was more frequent in group 3 than group 1. Free Androgen Index (FAI) and thyroid-stimulating hormone (TSH) levels were lower in group 1 than in groups 2 and 3. Progesterone and sex hormone-binding globulin (SHBG) levels were higher in group 1 than in groups 2 and 3. Dehydroepiandrosterone sulfate (DHEA-S) was higher in group 1 than group 3.CONCLUSIONS:
Obese and overweight infertile Mexican women with PCOS, attending to an infertility clinic, have a higher prevalence of IR and pre-diabetes compared with normal-weight women with PCOS. Therapeutic interventions should include those that improved metabolic functioning prior to attempting pregnancy in these groups of women.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
/
Estado Pré-Diabético
/
Resistência à Insulina
/
Infertilidade Feminina
/
Obesidade
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
Limite:
Adult
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Female
/
Humans
País/Região como assunto:
Mexico
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article