Neuroprotective and Anti-Inflammatory Effects of Diphenylheptanes from the Fruits of Amomum tsaoko, a Chinese Spice.
Plant Foods Hum Nutr
; 71(4): 450-453, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-27452308
ABSTRACT
Two novel diphenylheptanes, 2,3- dihydro-2 - (4' - hydroxy-phenylethyl) - 6 - [(3â³,4â³ - dihydroxy-5" - methoxy) phenyl] -4 - pyrone (CG-A) and 4 - dihydro-2 - (4' - hydroxy-phenylmethyl) -6 - [(3",4â³ - dihydroxy-5â³ - methoxyphenyl) methylene]-pyran-3, 5 - dione (CG-B), were isolated from the dried fruits of Amomum tsaoko, a commercially important spice. This study was designed to investigate their protective effects against H2O2-induced nerve injury, using PC-12 cells to determine the cell cytotoxicity and cell viability. The inhibitory effect on (nitric oxide) NO production was also determined in (lipopolysaccharide) LPS-stimulated macrophage RAW 264.7 cells. The results showed that CG-A and CG-B displayed significant neuroprotective effect and exhibited anti-inflammatory activity in a dose-dependent manner. These findings suggest that CG-A and CG-B are very important nutritional ingredients responsible for the neuroprotective and anti-inflammatory health benefits of A. tsaoko.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Especiarias
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Fármacos Neuroprotetores
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Amomum
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Frutas
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Heptanos
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article