Multiple siRNA delivery against cell cycle and anti-apoptosis proteins using lipid-substituted polyethylenimine in triple-negative breast cancer and nonmalignant cells.

Parmar, Manoj B; Arteaga Ballesteros, Bárbara E; Fu, Timothy; K C, Remant Bahadur; Montazeri Aliabadi, Hamidreza; Hugh, Judith C; Löbenberg, Raimar; Uludag, Hasan

Parmar, Manoj B; Arteaga Ballesteros, Bárbara E; Fu, Timothy; K C, Remant Bahadur; Montazeri Aliabadi, Hamidreza; Hugh, Judith C; Löbenberg, Raimar; Uludag, Hasan.

Afiliação

Parmar MB; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Arteaga Ballesteros BE; Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, Alberta, Canada.
Fu T; Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, Alberta, Canada.
K C RB; Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, Alberta, Canada.
Montazeri Aliabadi H; School of Pharmacy, Chapman University, Irvine, California, USA.
Hugh JC; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Löbenberg R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Uludag H; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada. hasan.uludag@ualberta.ca.

J Biomed Mater Res A ; 104(12): 3031-3044, 2016 12.

Article em En | MEDLINE | ID: mdl-27465922

Assuntos

Técnicas de Transferência de Genes; Lipídeos/química; Polietilenoimina/química; RNA Interferente Pequeno/administração & dosagem; Terapêutica com RNAi; Neoplasias de Mama Triplo Negativas/terapia; Proteínas Cdc20/genética; Proteínas de Ciclo Celular/genética; Linhagem Celular; Linhagem Celular Tumoral; Feminino; Humanos; Proteínas Inibidoras de Apoptose/genética; Proteínas Serina-Treonina Quinases/genética; Proteínas Tirosina Quinases/genética; Interferência de RNA; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/uso terapêutico; Survivina; Neoplasias de Mama Triplo Negativas/genética

Palavras-chave

amphiphilic polymers; anti-apoptosis protein; breast cancer therapy; cell cycle protein; siRNA delivery

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoimina / Técnicas de Transferência de Genes / RNA Interferente Pequeno / Neoplasias de Mama Triplo Negativas / Terapêutica com RNAi / Lipídeos Limite: Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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