Upregulation of miR-522 is associated with poor outcome of hepatocellular carcinoma.
Eur Rev Med Pharmacol Sci
; 20(15): 3194-8, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-27466991
ABSTRACT
OBJECTIVE:
The aim of our study was to explore the clinicopathologic and prognostic significance of miR-522 expression in human hepatocellular carcinoma (HCC). PATIENTS ANDMETHODS:
The expression of miR-522 in 161 HCC tissues and adjacent non-tumor tissues was examined using quantitative real-time-PCR. The association of miR-522 expression with clinicopathological features and the prognosis of HCC patients were also analyzed. The overall survival (OS) was analyzed by log-rank test. Cox regression models were fitted to analyze the effect of prognostic factors on OS.RESULTS:
The relative level of miR-522 was significantly higher in HCC tissues compared to the adjacent normal liver tissues. In addition, miR-522 upregulation more frequently occurred in HCC specimens with lymph node metastasis (p = 0.000), and tumor grade (p = 0.002). Moreover, the level of miR-522 expression was markedly correlated with the HCC patients' overall survival (p < 0.000). In the Cox proportional hazard model, the results showed that miR-522 overexpression was an independent prognostic factor for OSCONCLUSIONS:
Overexpression of miR-522 functions as an unfavorable prognostic biomarker in HCC patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article