Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease.

Wei, Guoxian; Tian, Na; Siezen, Roland; Schuppan, Detlef; Helmerhorst, Eva J

Wei, Guoxian; Tian, Na; Siezen, Roland; Schuppan, Detlef; Helmerhorst, Eva J.

Afiliação

Wei G; Department of Molecular and Cell Biology, Henry M. Goldman School of Dental Medicine, Boston, Massachusetts;
Tian N; Department of Molecular and Cell Biology, Henry M. Goldman School of Dental Medicine, Boston, Massachusetts;
Siezen R; Bacterial Genomics Group, Center for Molecular and Biomolecular Informatics, Radboud University Medical Centre, Nijmegen, the Netherlands;
Schuppan D; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; and Institute of Translational Immunology and Research Center for Immunology, University Medical Center, Johannes-Gutenberg-University, Mainz, Germany.
Helmerhorst EJ; Department of Molecular and Cell Biology, Henry M. Goldman School of Dental Medicine, Boston, Massachusetts; helmer@bu.edu.

Am J Physiol Gastrointest Liver Physiol ; 311(3): G571-80, 2016 09 01.

Article em En | MEDLINE | ID: mdl-27469368

Assuntos

Bactérias/enzimologia; Glutens/metabolismo; Subtilisinas/metabolismo; Extratos Celulares; Epitopos/metabolismo; Gliadina/metabolismo

Palavras-chave

Bacillus; Rothia; celiac disease; gluten; therapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Subtilisinas / Glutens Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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