Hypoxia-induced resistance to cisplatin-mediated apoptosis in osteosarcoma cells is reversed by gambogic acid independently of HIF-1&#945;.

Zhao, Wei; Xia, Shi-Qi; Zhuang, Jin-Peng; Zhang, Zhi-Peng; You, Chang-Cheng; Yan, Jing-Long; Xu, Gong-Ping

Hypoxia-induced resistance to cisplatin-mediated apoptosis in osteosarcoma cells is reversed by gambogic acid independently of HIF-1α.

Zhao, Wei; Xia, Shi-Qi; Zhuang, Jin-Peng; Zhang, Zhi-Peng; You, Chang-Cheng; Yan, Jing-Long; Xu, Gong-Ping.

Afiliação

Zhao W; Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, 148 Baojian Road, Harbin, 150081, China.
Xia SQ; Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, 148 Baojian Road, Harbin, 150081, China.
Zhuang JP; Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, 148 Baojian Road, Harbin, 150081, China.
Zhang ZP; Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, 148 Baojian Road, Harbin, 150081, China.
You CC; Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, 148 Baojian Road, Harbin, 150081, China.
Yan JL; Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, 148 Baojian Road, Harbin, 150081, China. yanjinglong@hotmail.com.
Xu GP; Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, 148 Baojian Road, Harbin, 150081, China. 30621708@qq.com.

Mol Cell Biochem ; 420(1-2): 1-8, 2016 Sep.

Article em En | MEDLINE | ID: mdl-27473145

Assuntos

Apoptose/efeitos dos fármacos; Cisplatino/farmacologia; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Osteossarcoma; Xantonas/farmacologia; Animais; Hipóxia Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Camundongos; Proteínas de Neoplasias/metabolismo; Osteossarcoma/tratamento farmacológico; Osteossarcoma/metabolismo; Osteossarcoma/patologia; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Cisplatin; Gambogic acid; HIF-1α; Hypoxia; Osteosarcoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteossarcoma / Cisplatino / Apoptose / Resistencia a Medicamentos Antineoplásicos / Xantonas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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