(68)Ga-labeled phage-display selected peptides as tracers for positron emission tomography imaging of Staphylococcus aureus biofilm-associated infections: Selection, radiolabelling and preliminary biological evaluation.

Nielsen, Karin M; Kyneb, Majbritt H; Alstrup, Aage K O; Jensen, Jakob J; Bender, Dirk; Schønheyder, Henrik C; Afzelius, Pia; Nielsen, Ole L; Jensen, Svend B

Nielsen, Karin M; Kyneb, Majbritt H; Alstrup, Aage K O; Jensen, Jakob J; Bender, Dirk; Schønheyder, Henrik C; Afzelius, Pia; Nielsen, Ole L; Jensen, Svend B.

Afiliação

Nielsen KM; Department of Nuclear Medicine, Aalborg University Hospital, DK-9000 Aalborg, Denmark; Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870 Copenhagen, Denmark. Electronic address: karin.michaelsen.nielsen@regionh.dk.
Kyneb MH; Section for Medical Biotechnology, Danish Technological Institute, DK-8000 Aarhus, Denmark.
Alstrup AK; Department of Nuclear Medicine and PET-centre, Aarhus University Hospital, DK-8000 Aarhus, Denmark.
Jensen JJ; Department of Nuclear Medicine, Aalborg University Hospital, DK-9000 Aalborg, Denmark; Section for Medical Biotechnology, Danish Technological Institute, DK-8000 Aarhus, Denmark.
Bender D; Department of Nuclear Medicine and PET-centre, Aarhus University Hospital, DK-8000 Aarhus, Denmark.
Schønheyder HC; Department of Clinical Microbiology, Aalborg University Hospital, DK-9000 Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, DK-9000 Aalborg, Denmark.
Afzelius P; Department of Diagnostic Imaging, Section of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, North Zealand, DK-3400 Hillerød, Denmark.
Nielsen OL; Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870 Copenhagen, Denmark.
Jensen SB; Department of Nuclear Medicine, Aalborg University Hospital, DK-9000 Aalborg, Denmark; Department of Chemistry and Biochemistry, Aalborg University, DK-9000 Aalborg, Denmark.

Nucl Med Biol ; 43(10): 593-605, 2016 10.

Article em En | MEDLINE | ID: mdl-27474962

Assuntos

Biofilmes; Radioisótopos de Gálio; Oligopeptídeos/química; Biblioteca de Peptídeos; Tomografia por Emissão de Pósitrons/métodos; Infecções Estafilocócicas/diagnóstico por imagem; Staphylococcus aureus/fisiologia; Sequência de Aminoácidos; Animais; Estabilidade de Medicamentos; Feminino; Humanos; Camundongos; Oligopeptídeos/farmacocinética; Traçadores Radioativos; Radioquímica; Suínos

Palavras-chave

(68)Ga-A9-K-DOTA; Biofilm; Infection imaging; Pet; Phage-display; Staphylococcus aureus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Infecções Estafilocócicas / Staphylococcus aureus / Biofilmes / Biblioteca de Peptídeos / Tomografia por Emissão de Pósitrons / Radioisótopos de Gálio Tipo de estudo: Risk_factors_studies / Screening_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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