Metabolism of Carfentanil, an Ultra-Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass Spectrometry.

Feasel, Michael G; Wohlfarth, Ariane; Nilles, John M; Pang, Shaokun; Kristovich, Robert L; Huestis, Marilyn A

Feasel, Michael G; Wohlfarth, Ariane; Nilles, John M; Pang, Shaokun; Kristovich, Robert L; Huestis, Marilyn A.

Afiliação

Feasel MG; Edgewood Chemical Biological Center, Research Development and Engineering Command, U.S. Army, 5183 Blackhawk Road, Gunpowder, Maryland, 21010-5424, USA. michael.g.feasel.civ@mail.mil.
Wohlfarth A; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, 21224, USA.
Nilles JM; Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, 58758, Linköping, Sweden.
Pang S; Division of Drug Research, Department of Medical Health Sciences, Linköping University, 58185, Linköping, Sweden.
Kristovich RL; Excet, Inc., Springfield, Virginia, 22150, USA.
Huestis MA; Sciex, Foster City, California, 94404, USA.

AAPS J ; 18(6): 1489-1499, 2016 11.

Article em En | MEDLINE | ID: mdl-27495118

Assuntos

Analgésicos Opioides/metabolismo; Fentanila/análogos & derivados; Hepatócitos/metabolismo; Microssomos Hepáticos/metabolismo; Fentanila/metabolismo; Humanos; Espectrometria de Massas em Tandem

Palavras-chave

carfentanil; metabolism; norcarfentanil; opioid

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Fentanila / Hepatócitos / Analgésicos Opioides Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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