Simultaneous quantitation of trace level hydrazine and acetohydrazide in pharmaceuticals by benzaldehyde derivatization with sample 'matrix matching' followed by liquid chromatography-mass spectrometry.

Cui, Li; Jiang, Kaina; Liu, David Q; Facchine, Kevin L

Cui, Li; Jiang, Kaina; Liu, David Q; Facchine, Kevin L.

Afiliação

Cui L; Analytical Sciences and Development, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA. Electronic address: li.x.cui@gsk.com.
Jiang K; Analytical Sciences and Development, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
Liu DQ; Analytical Sciences and Development, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
Facchine KL; Analytical Sciences and Development, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.

J Chromatogr A ; 1462: 73-9, 2016 Sep 02.

Article em En | MEDLINE | ID: mdl-27495371

Assuntos

Benzaldeídos/química; Hidrazinas/análise; Preparações Farmacêuticas/química; Cromatografia Líquida; Espectrometria de Massas

Palavras-chave

Acetohydrazide; Derivatization; Hydrazine; LCMS; Quantification; Trace level

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzaldeídos / Preparações Farmacêuticas / Hidrazinas Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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